Functional dissection of core spliceosomal mutations causing Retinitis Pigmentosa. Bach PB et al. Use of novel techniques to identify pathogenic versus non-pathogenic TH17 cells in experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis. Protecting patients with enhanced susceptibility to infections, Eye fundus colour images enhancement service for Diabetic Retinopathy diagnosis, Highly efficient and eco-innovative probiotic food supplement for antibiotic-associated disorders prevention, Feasibility study on Opto-Magnetic Imaging Spectroscopy for cancer screening, Feasibility study to evaluate a novel prostate cancer diagnostic. A revolutionary new orthotics service—consultation to delivery in less than a week. ScreenCancer Mole Scanner - Easily accessible mole scanning service for early detection of skin cancer. Function of DUX4 in skeletal muscle and non-muscle tissues, Tracking the temporal and geographic origins of modern domestic horses, Enhancing Engulfment of Apoptotic cells: basic biology to Therapy, From marine molecules to eco-friendly tools for agriculture, Progeria models to study endothelial cell ageing: implications for organ regeneration and fibrosis, Advancing the non-invasive assessment of brain communication in neurological disease, Building biological computers from bacterial populations. New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling. In-mouth drilling robots for automating tooth repair and scaling dentist revenues, We are developing ground-breaking therapeutics to cure currently untreatable respiratory infections affecting children and the elderly, Next generation allergen immunotherapy based on specifically modified recombinant hypoallergens, Vaccines and Infectious Diseases in the Ageing PopuLation, SECRETED FACTORS IN CARDIAC REMODELING PROVOKE TUMORIGENESIS AND END ORGAN DAMAGE IN HEART FAILURE, SWALLIS - a disruptive wearable device that uses sound patterns to diagnose and monitor swallowing disorders, Cellular modulation by the mitochondrial unfolded protein response, Communicable Disease in the Age of Seafaring, Psychiatric Disorders: ATX-inhibiting drugs as a new therapeutic option: Proof-of-Concept, African Research and Innovative Initiative for Sickle cell Education: Improving Research Capacity for Service Improvement, Colorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeutical Testing, Massive reutilization of Electronic Health Records (EHRs) through AI to enhance clinical research and precision medicine, New wearable measurement devices for Industry 4.0 based on gaming motion-capture system, PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL, Programmable nucleic acid toolkits for cell-free diagnostics and genetically encoded biosensing, ChaperoneRegulome: Understanding cell-type-specificity of chaperone regulation, Supramolecular engineering of glycan-decorated peptides as synthetic vaccines, Charting key molecules and mechanisms of human immune Dysregulation, ARCHITECTURE AND TOOLS FOR THE QUERY OF ANTIBODY AND T-CELL RECEPTOR SEQUENCING DATA REPOSITORIES FOR ENABLING IMPROVED PERSONALIZED MEDICINE AND IMMUNOTHERAPY, Development of RGD-therapeutics for cardio-metabolic disease, Integrated human data repositories for infectious disease-related international cohorts to foster personalized medicine approaches to infectious disease research, Common Infrastructure for National Cohorts in Europe, Canada, and Africa, A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health, Biomarker discovery by AI-guided, image based single-cell isolation proteomics, cAMP-dependend plasticity of striatal projection neurons in health and disease, New biological control agents against European fruit tree canker disease (Neonectria ditissima) in apple: from microbiome analysis towards product development, A Single-Molecule Technology for Resolving Chaperone Action in Neurodegenerative Diseases, Intra-tumoral heterogeneity in NRAS-driven metastatic melanoma, Using a novel protein degradation approach to uncover IRF4-regulated genes in plasma cells, Investigating the Therapeutic Potential of Persulfides: Implications of their Roles in Cardiovascular Disease, Tracking the Effects of Amyloid and Tau Pathology on Brain Systems and Cognition in Early Alzheimer’s Disease. Blood-brain barrier: from molecular mechanisms to intervention strategies, Molecular Principles of Mammalian Axonemal Dynein Assembly, MALDI-TOF mass spectrometry metabolite screening assays for drug discovery in human disease, ImmunoPET directed to specific subtypes of GABAA receptors as strategy for molecular mapping of behaviour and mental illness, The role of the serotonin 5-HT4 receptor in motor and non-motor symptoms of Parkinson’s disease, Virulence Activities of the Metalloprotease Effector AVR-Pita from the rice blast fungus Magnaporthe oryzae, Exploring the non-genetic (i.e. Generation of new zebrafish models for the study of the pathogenesis of Huntington´s disease and for the identification of new therapeutic targets. Micro/Nano Robotics for Single Cancer Cells, How to help the hive? The polyphosphate/factor-XII pathway in cancer-driven thrombosis and tumor growth, MicroRNA Isoforms for Molecular Interception of Cervical cancer using Self-samples, Assistive Devices for the Visually Impaired and other Disabilities, Discovery and commercialisation of novel compounds targeting redox proteins, Neogenesis of new functional Beta Cells through Modulation of Neurogenin-3 Expression to provide Regenerative Therapy for Diabetes Patients, Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution, polyValent mEsopoRous nanosystem for bone DIseases, Brain network based stratification of mental illness, Composition and Mechanism of the DNA-uptake Pilus of Vibrio cholerae, Mechanisms of cellular fatty acid homeostasis, Bendable Bioplatform for Electrically stimulated Neuronal Differentiation. dohowblood Chronic (long term) kidney disease (CKD) caused by diabetes always affects both ... going on dialysis, getting a kidney transplant or conservative treatment. These bams are a subset of the sequencing restricted specifically to the GRCh37 coding areas of the BAP1 gene. Glick S, Abrams R, Buchanan D, Cohen M, Francis L, Lemon M, McAuley J, Riordan K, Rohr L, Smith J, Whitaker E. Teaching A study for the technical and business feasibility of a fast-acting consumer test to detect gluten and other contaminants in food. Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies. Discovering the cellular landscape of the airways and the lung, EXposome Powered tools for healthy living in urbAN SEttings, Molecular atlas of the brain across the human lifespan, Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases, Impact of exposome on the course of lung diseases, Versatile Emerging infectious disease Observatory, Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome, New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes, Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts, Human Exposomic Determinants of Immune Mediated Diseases, MOnitoring Outbreak events for Disease surveillance in a data science context, Dipeptide-Repeat Vaccine to prevent ALS and FTD in C9orf72 mutation carriers, ENDObronchial microWAVE Ablation for the minimally invasive treatment of lung cancer, Wearable Sweat-based painless and continuous glucose monitoring device for diabetic people, Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe, Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren), EUROPEAN REGIMEN ACCELERATOR FOR TUBERCULOSIS, Understanding how mitochondria compete with Toxoplasma for nutrients to defend the host cell. Cellular substrate of abnormal network maturation in neuropsychiatric disorders. Biological Effects on Isotopically Evaluated Systems, Reactivation of the Fanconi anemia-BRCA pathway in cells carrying patient-derived missense mutations: finding a drug to cure Fanconi anemia, Elucidating the involvement of neutrophils in the pathogenesis of tuberculosis using a zebrafish model, Algorithmic Containment of Threats in Graphs, Networks or Webs, Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish, Determinants of Xylella fastidiosa host specificity, Exploring glycosidic neo-epitopes of degenerative hippocampal granules in aged mice and humans: implications for ageing and dementia, Mechanisms of Myelination – Elucidating the Diversity of Oligodendroglial Precursors and their Local Axon-Glia Interactions, Functional genomics of non-coding mutations in regulatory regions of four metabolic tissues, and their involvement into type 2 diabetes through large-scale sequencing, Novel Therapeutic Avenues for dynein-related Ciliopathies, The role of tumour microenvironment in metastatic hormone-refractory prostate cancer, Mechanics of cells: the role of intermediate filaments, Haptic micromanipulation system for low cost autonomous microinjection tasks, A next-generation platform for catalysing pre-clinical development of drugs against Alzheimer’s and other degenerative diseases of old-age, PIK3CA inhibition in patients with the CLOVES syndrome, Viral Vaccine Vectors in Personalized Medicine, A Drug Discovery and Target Identification Screening Platform for Age-Associated Neurodegenerative Disorders, An innovative, non-invasive and de-risked system to enable the transdermal delivery of fragile therapeutic compounds for a better management of painful diseases, First in class epithelial Barrier-enhancing medicine for respiratory diseases, Innovative combination therapy against bladder cancer, A novel weaning diet to optimize performance of farmed shrimp larvae, Understanding the mechanisms of human acute myeloid leukaemia (AML) evolution, Chemical proteome mining for functional annotation of disease relevant proteins, A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes, Novel Arthritis Treatment with focus on natural Chitin Oligosaccharides, From symptom relief to disease modifying allergy treatment with Glycan-Allergen Immunotherapy, Hannover – automatic monitoring of horses, Bacterial Ghost Cancer Immunotherapy - A new standard in tumour therapy based on the bacterial ghost platform technology, A scientifically proven, safe, naturally derived drug for the effective treatment of liver damage - an innovative solution for a significant unmet medical need, Accurate irrigation controller with multi-sensoring and interactive cloud-based platform to evaluate real plant needs and save up to 80% of water, The HepaRG-Bio-Artificial Liver: Feasibility of commercialization and expansion of business plan. Non-histone protein acetylation targets of KAT2A in AML, Human Lung Microbiota And Innate Immunity. Modular DNA Origami Platform for the Design of Tunable Glucose Biosensor, Regulatory mechanisms controlling a new mechanical Epithelial to Mesenchymal Transition in zebrafish, ViSionRF: Vital Signal Monitoring using Radio-Frequency Technologies – Standard IF-RI, Elucidation of tumour cell plasticity mechanisms associated to treatment in metastatic prostate cancer, Investigating the Activity of transposon Derived Regulatory Sequences in the placenta, iPS-derived MIcroglia and Neuroinflammation in Dementia, Dissecting the impact of Lactate in Tuberculosis, Inhibitor of DUX4-IGH to Erase Acute lymphoblastic Leukaemia, Elucidating the impact of the microbiome on adipose tissue immune cell interactions during obesity, Innovative Electrochemical Multiplex Biosensor for Detection and Quantification of Clinically Relevant Circulating miRNAs, Hypothalamic Modulation of Neocortical States, Methyl Donating artificial organelles to support liver cells in Non-alcoholic fatty liver disease, Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules, Deciphering intrarenal communication to unvail mechanisms of chronic kidney diseases. Epigenetic Data Integrated in a Big Data Approach to Unravel Novel Pathzays of CV Risk independent of classical CVD Risk Factors in Women. Worm power: Can helminths modify the development of colorectal cancer? Development of a more effective and safer therapeutic antibody for cancer treatment with a dual mechanism of action to eliminate CSCs and reactivate the tumour’s immune system. Discovering functional protein-RNA interactions through data integration and machine learning. Association of air pollution with dementia risk: is it confounded and mediated by environmental tobacco smoke and consumption of fish? A novel in-vitro diagnostic test for drug-resistant tuberculosis and a personalized antibiotic treatment plan. Better Health with Lower Costs More Individually. Development of New therapies against cholangiopathies. : 116060, Single cell genomic analysis and perturbations of hematopoietic progenitors: Towards a refined model of hematopoiesis. Novel Target for Treatment of Chronic Inflammatory Diseases, Noninvasive cell specific morphometry in neuroinflammation and degeneration, Cognitive Aging: From Educational Opportunities to Individual Risk Profiles, Development and Commercialisation of an Intelligent Wearable Platforms to Stabilise Hand Tremors in Parkinson’s Disease and Essential Tremor, Oral bacteria as determinants for respiratory health, Navigation of a mind-space. A feasibility study on the development of Psorax35 as the first and only oral treatment for mild-to-moderate psoriasis with positive effects on co-morbidities. Microprocessing photovitamin D3 using photo-high-T intensification. Modeling spontaneous Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity. ePIgenetic) mechanisms that contribute to therapy Escape in melanoma, Normalization of Multimodal Brain Networks for Integral and Predictive Mapping of Neurological Disorders, The Sound of a Healthy Herd. Utilizing evolutionary interactions to limit multidrug resistance, A potent Micro-RNA therapeutic for nonalcoholic fatty liver disease (NAFLD), Amyotrophic Lateral Sclerosis from a cortical perspective: towards alternative therapeutic strategies, Cerebellar circuit mechanisms of coordinated locomotion in mice, Preclinical development of squalenic acid and gemcitabine squalene nanomedicine, Nano-diamond tracers for MRI molecular imaging, Development of a ncRNA DNA Methylation Kit for the Diagnosis of Cancer of Unknown Primary, COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma, Exploring the Potential for Therapeutic Lineage Reprogramming of Diabetes, Bringing CItizens, Models and Data together in Participatory, Interactive SociaL EXploratories, Zinc finger gene therapy in the brain for treating Huntington's disease. Bio-scaffold engineered device for brown adipose tissue regeneration, Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins. Why? : 115902, PERtussIS COrrelates of Protection Europe - Sofia ref. Program for Innovative Global Prevention of Streptococcus suis. Biological signal processing via multisite phosphorylation networks, DEVELOPMENT OF A SPIRAL LAMINAR FLOW INDUCING ENDOVASCULAR STENT FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASE. Identification and characterization of enteric nervous system stem cells, Study of the role of BANK1 in antibody production and antibody-independent functions of B cells in SLE, Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease, Targeting drug resistance in ovarian cancer through large-scale drug-response profiling in physiologically relevant cancer organoids, Evolutionary history of the sickle cell trait among Central African hunter-gatherers and farmers, Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders, Molecular Details of Membrane Protein Receptor Dynamics. The tick-borne Lyme disease AML, human Lung Microbiota and Innate immunity for home easy., analytical device for stroke prevention during heart valve replacement treatments for different types of in! And social welfare of Cystic Fibrosis patients in the Histopathology ( human tissue ) fixative market patients. 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